Potential Curative Effect of Curcumin on Gastric Ulcer Induced by Piroxicam in Male Albino Rats

Document Type : Original Article

Authors

1 Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Zagazig, Egypt

2 Pharmacology Department, Faculty of Medicine 44519, Zagazig University, Egypt

3 Health Institution, Ministry of Health 11516, Cairo, Egypt

Abstract

This study intended to investigate the curative effect of curcumin on piroxicam-induced gastric ulcer in rats. Twenty-seven male albino rats were allocated into three similar groups (9 of each). The firstgroup (G1) was the control, G2 received piroxicam (30 mg∕ kg BW.) to induce gastric ulcer and G3 received piroxicam (30 mg∕ kg BW.) and on the third day it received curcumin (200 mg ∕ kg BW.) orally for 21 day. At the end of the experiment, the rats were humanly euthazied and blood and serum samples were taken for haematological and biochemical analysis, respectively. Subsequently, the stomachs were opened along their curvature for evaluation of ulceration, gastric juice was measured and gastric samples were preserved in 10% neutral buffered formalin for histopathological examination. Piroxicam administration induced gastric ulceration (100%), non-significant changes in the gastric juice volume and a remarkable decrease in the number of red blood cells, hemoglobin concentration and packed cell volume with a significant increase in platelets count, white blood cells, neutrophils, eosinophils and monocytes. Furthermore, it displayed a significant reduction of glutathione peroxidase, superoxide dismutase and catalase activities with a significant increase in malondialdehyde and tumor necrosis factor alpha concentrations. Histopathological results revealed focal mucosal erosive and ulcerative changes with sever hyperemia of stomach in piroxicam treated group (G2). Oral administration of curcumin treated the piroxicam induced gastric ulceration and improved the altered hematological parameters, oxidant ∕ antioxidant status and histological pictures of rats in G3. Therefore, curcumin may offer an attractive strategy for treatment of gastric ulcer.

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