Biochemical Effect Of L-Carnitine Against Doxorubicin And Vancomycin Induced Lipid Disorders In Rats

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The ameliorative effect of L-carnitine on the lipid, liver and kidneys disorders induced by doxorubicin and vancomycin was examined. Ninety male albino rats were randomly divided into six groups (15) each; control, L-carnitine treated, Doxorubicin treated, vancomycin treated, doxorubicin + L-carnitine, Vancomycin + L-carnitine. Animals were sacrificed after 3, 10, 15 days. Blood and tissue samples were collected. Leptin, insulin, MDA, HDL, TC, TP and albumin levels, LDH and GGT activities were determined. mRNA expression levels of leptin, leptin receptors and GAPDH genes were determined in adipose tissues. There was a significant increase of serum insulin, leptin, MDA, HDL, TC levels, GGT and LDH activities and significant decrease of Albumin, TP levels in the groups treated with doxorubicin and Vancomycin. In conclusion, DOX and VAN had a bad effect on the lipid profile as they induced obesity. Also they increased the liver enzymes, heart markers and the oxidative stress in body tissues due to their ability to increase the level of MDA. L-carnitine administration ameliorated the hazards effect of DOX and VAN on the lipid sate in the body.

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