Document Type : Original Article
Authors
1
Department of Animal Medicine (Internal Medicine), Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
2
Veterinary Hospital, Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
3
Department of Pathology, Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
4
Department of Surgery, Faculty of Veterinary Medicine 44511, Zagazig University, Zagazig, Sharkia Governorate, Egypt
Abstract
Hepatorenal syndrome (HRS) is a unique form of functional and potentially reversible renal failure secondary to liver diseases. It occurs typically in kidneys that are histologically normal. In this study, the hepatorenal syndrome was observed in a model of extrahepatic biliary stasis. Seven mature male mongrel dogs were subjected to complete surgical ligation of common bile duct at the duodenal region Clinical, ultrasonographic, , histopathological examinations along with biochemical analysis for liver enzymes and urinalysis were performed before and throughout the experimental periods. Clinical observations post-surgery revealed icteric mucosa, abdominal pain, weight loss, dehydration, orange-colored urine, bilirubinurea, and clay feces. Biochemical analysis showed an abrupt increase in the mean values of serum blood urea nitrogen and creatinine from the 3rd day till reaching the peak at the 2nd week post-surgery. A strong positive correlation was detected between BUN and creatinine, and serum total and direct bilirubin. Ultrasonographic findings of liver revealed a progressive dilatation of gallbladder and the common bile duct from the 3rd day post-ligation, with an increase in the echogenicty of the liver, whereas, the kidneys demonstrate normal renal parenchyma and dimensions. Histopathological examination of the kidney revealed hemorrhage, vacuolation, hyaline droplet were observed in renal tubules and edema and yellowish-brown granules were seen in the interstitial tissue, but the significant renal changes that refer to renal failure weren’t detected,. In conclusion, the dogs are considered a suitable model for studying hepatorenal syndrome and also there is an association between obstructive jaundice and renal failure.
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