The Possible Protective Effect of Galantamine against Paracetamol Induced Hepatic and Renal Toxicity in Rats

Document Type : Original Article

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Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, ‎‎44511 Zagazig, Egypt‎

Abstract

Paracetamol (PCM) is a pain reliever that is also used as an antipyretic and an analgesic ‎after surgery. Overdoses, such as those used in suicide attempts or unintentional ‎mishaps, can produce hepatotoxicity, which can result in rapid liver failure and renal ‎necrosis. Galantamine (GAL) is a reversible and competitive cholinesterase inhibitor ‎that is used to treat Alzheimer's disease and other memory-related diseases. This study ‎aimed to investigate the possible protective role of GAL (0.3 mg/kg P.O) for successive ‎‎28 days against PCM (2 g/kg BW P.O) toxicity on day 29 of the experiment. At day ‎‎30, blood samples were collected for evaluation of liver function such as serum alkaline ‎phosphatase (ALP), alanine transaminase (ALT), aspartate aminotransferase (AST), ‎total protein, albumin, globulin, albumin/globulin (A/G) ratio and kidney function (urea ‎and creatinine). The obtained results revealed that GAL decreased the levels of ALT, ‎AST, ALP, urea, creatinine and improved the protein profile in comparison with PCM ‎treated group. In conclusion, GAL had a protective effect against PCM toxicity by ‎improving liver and kidney function against hepatic and renal toxicity induced by PCM ‎in rats‎.

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