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Volume Volume 49 (2021)
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fawzy, M., abdelfattah, D., ibrahim, R. (2021). glutathione metabolism in rats fed high fat diet and effect of curcumin treatment. Zagazig Veterinary Journal, 49(1), 131-148. doi: 10.21608/zvjz.2021.50988.1129
medhat fawzy; doaa mohammed abdelfattah; reham abdelsalam ibrahim. "glutathione metabolism in rats fed high fat diet and effect of curcumin treatment". Zagazig Veterinary Journal, 49, 1, 2021, 131-148. doi: 10.21608/zvjz.2021.50988.1129
fawzy, M., abdelfattah, D., ibrahim, R. (2021). 'glutathione metabolism in rats fed high fat diet and effect of curcumin treatment', Zagazig Veterinary Journal, 49(1), pp. 131-148. doi: 10.21608/zvjz.2021.50988.1129
fawzy, M., abdelfattah, D., ibrahim, R. glutathione metabolism in rats fed high fat diet and effect of curcumin treatment. Zagazig Veterinary Journal, 2021; 49(1): 131-148. doi: 10.21608/zvjz.2021.50988.1129

glutathione metabolism in rats fed high fat diet and effect of curcumin treatment

Article 8, Volume 49, Issue 1, Winter 2021, Page 131-148  XML PDF (389.13 K)
Document Type: Original Article
DOI: 10.21608/zvjz.2021.50988.1129
Authors
medhat fawzy1; doaa mohammed abdelfattah2; reham abdelsalam ibrahim email 3
1biochemistry department faculty of veterinary medecine,zagazig university
2biochemistry faculty of veterinary medecine,zagazig university
3biochemistry department,faculty of veterinary medecine,zagazig university
Abstract
The present study was designed to study the protective effect of curcumin and the bad effects of dietary high fat diet (beef tallow) which causes non alcoholic fatty liver disease which is very harmful affecting health ,also our study was designed to study the important role of curcumin against HFD-induced obesity, on glutathione state ( total glutathione ,Reduced glutathione ,oxidized glutathione ,glutathione Quotient)as well as the activity of glutathione reductase and glutathione peroxidase in hepatic tissue together with serum insulin,serum blood glucose , triglycerides ,total cholesterol,HDL,LDL,VLDL, total bilirubin, malondialdhyde and following body weight gain in the experiment . We prepared and divided 60 rats weighs range (165:170g) equally in 4 groups (control-curcumin –HFD- (HFD+curcumin)) for 12 weeks . our results shows a significant increase in the hepatic glutathione state and serum level of insulin in both curcumin group when compared to control and also in HFD+curcumin when compared to HFD group . asignificant decrease in blood glucose ,lipid profile ,MDA and body weight gain.In the contrast ,a significant decrease in hepatic glutathione state and serum insulin and a significant increase in serum blood glucose, lipid profile ,total bilirubin ,MDA,reduction of serum insulin and increase in the body weight gain
Keywords
Non alcoholic fatty liver disease; glutathione peroxidase(GPX); Glutathione reductase (GR); Curcumin; HFD
Main Subjects
Academic and Pre-clinical Veterinary Sciences (Physiology, Histology, Anatomy, Biochemistry, Microbiology, Virology, Parasitology, Pharmacology, Forensic Medicine and Toxicology)
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