Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
Effects of trans-Fatty Acid on Lipoproteins-a, Oxidative Status and Expression of Leptin and Leptin Receptor Genes in Albino Rats
1
12
EN
Ali
AbdElA-al
yasmin
October 6 university
yasmin-ali.ams@o6u.edu.eg
khalifa
El-Dawy
Professor of Biochemistry & Vice Dean for Postgraduates and Researches
Faculty of Veterinary Medicine
Zagazig University
khalifadawy@yahoo.com
doaa
mohamed
Abdel-Fattah
biocemistry, Faculty of Veterinary Medicine, Zagazig University, zagazig,egypt
drdoaa30@yahoo.com
Ahmed
Hamed
Arisha
0000-0002-1330-6311
Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt
vetahmedhamed@yahoo.com
mohamed
badawi
Clinical Nutrition Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, El-sharkia, Egypt
mohamed.ali.iprint@gmail.com
10.21608/zvjz.2021.54386.1127
High consumption of <em>trans</em>-fatty acids (TFAs) linked with obesity, disorders of lipoproteins, type 2 Diabetes Mellitus (T2DM), risk factors of coronary heart disease, and development of atherosclerosis. The intent of our trials was to assess the possible bad impact of TFAs on the lipid status and focusing on characterizing the physiological alters in an animal model comparing with <em>cis</em> fatty acids. Sixty male albino rats, with nearly similar average weight 170±5wereassignedinto 4 main groups (15 rats per group) and kept on a standard diet set for 12 weeks. All groups received different diet treatment for successive 12 weeks. Group A: control group received a conventional diet, group B received a diet contained 360 gm TFAs inform of partially hydrogenated vegetable oil (PHVO) l kg of diet, group C was fed a High Fat Diet (HFD) contained 360 gm beef tallow l kg of diet for, and group D received a diet containing 360 gm linseed oil l kg of diet. Both feeding of TFAs and HFD resulted in a marked increase in the body weight in reach to the obesity grade with a significant increase (<em>P</em>≤0.05) in leptin and leptin receptor gene expression. Also, a significant increase in Malondialdehyde (MDA) and Lipoprotein-a (Lp-a) and a marked decrease in total antioxidant capacity (TAC). It could be concluded that TFAs induce combined increased body weight, with imbalance in oxidative stress, dyslipidemia, and elevated atherogenic Lipoprotein-a may be leading to development of atherosclerosis and coronary heart disease.
trans-fatty acids,Lipoprotein (a),Obesity,Coronary heart disease,leptin resistance
https://zvjz.journals.ekb.eg/article_160265.html
https://zvjz.journals.ekb.eg/article_160265_374de467deee864574729ef32334455e.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
Pathophysiology of osteoarthritis and Current Treatment
13
26
EN
Abdelmoneim
Ali
Pathology Department, Faculty of Vet Med,Zagazig University
abdelmoneim.ahmedali@yahoo.com
10.21608/zvjz.2021.40197.1117
Osteoarthritis (OA) is considered the prevalent arthritis in human and some animals, causing joint pain and disability that reduces quality of life. The exact etiology of OA is unknown till now but there is a variety of predisposing factors for the occurrence of osteoarthritis (OA) such as previous joint injury, genetics, obesity, sex, anatomical abnormalities and excessive load; meanwhile, the predominant factor is ageing. Understanding the pathophysiology of osteoarthritis is a must to provide effective treatment options. Previous researches had studied the pathophysiology of osteoarthritis However several controversies still present. Currently still there is no substantial therapy for OA; treatment options concentrate on the relief of signs. The main goals of therapy are pain relief, improved joint function, and joint stability. New trials of therapies are under study and some of them did promising effects as approaches to regenerative medical therapies such as Platelet Rich Plasma (PRP) and Nanotechnology. The purpose of this study is to provide an overview of pathophysiology information and of the various therapeutic resources suitable for OA.
Osteoarthritis(OA),articular cartilage,Interlukin 1β,Platelet rich plasma (PRP),Nanocurcumin
https://zvjz.journals.ekb.eg/article_160267.html
https://zvjz.journals.ekb.eg/article_160267_f60f82f5d555b548ed88f817c334b7be.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
Prevalence, antimicrobial resistance, and biofilm formation of Klebsiella pneumoniae isolated from human and cows
27
41
EN
Noha
Ali
Gomaa
Department of bacteriology, Faculty of veterinary medicine, Zagazig university, Zagazig, Egypt
dr.noha_3li@yahoo.com
10.21608/zvjz.2021.51857.1126
Klebsiella pneumoniae (K. pneumoniae) is an important multidrug-resistant (MDR) and biofilm producing pathogen that causes diverse infections in human and animals. This study aimed to evaluate the prevalence, antimicrobial resistance, and biofilm forming ability of K. pneumoniae isolates from diseased humans sputum and urine samples and mastitic cows milk samples in Zagazig city, Sharkia Governorate, Egypt. A total of 100 human and animal samples were collected and examined for the presence of Klebsiella species. The recovered isolates were identified by conventional bacteriological procedures and confirmed by the traditional PCR at the genus and species levels using gyrA, 16S-23S ITS and pehX genes, respectively. The confirmed K. pneumoniae isolates were subjected for testing their antimicrobial susceptibility and biofilm formation ability. The results revealed that 10 out of 50 human samples were positive for K. pneumoniae (20%); 28% (7/25) from sputum samples and 12% (3/25) from urine samples. Additionally, the prevalence rate of K. pneumoniae in milk samples from mastitic cows was 4% (2/50). PCR assays confirmed the 12 isolates as K. pneumoniae. The antimicrobial susceptibility results showed that K. pneumoniae isolates had high resistance rates to ampicillin and ampicillin/clavulanate (100% each) with multiple antibiotic resistance (MAR) index of 0.083, followed by azithromycin, cefepime, and trimethoprim/sulphamethoxazole (91.7% each). Meanwhile, these isolates revealed high sensitivity levels to chloramphenicol (83.3%) with MAR index of 0.014. Furthermore, 91.7% of K. pneumoniae isolates were able to produce the biofilm, where 8.3% was a non-biofilm producer. Out of 11 K. pneumoniae isolates, 6 (54.5%), 3 (27.3%) and 2 (18.2%) were moderate, strong and weak biofilm producers, respectively. The present study emphasized the high prevalence of MDR and biofilm producing K. pneumoniae isolates in human sputum and urine samples. Therefore, more attentions should be taken against antimicrobials usage and for providing new antibiofilm approaches against Klebsiella species biofilms.
Klebsiella pneumoniae,prevalence,Antimicrobial resistance,Biofilm
https://zvjz.journals.ekb.eg/article_160272.html
https://zvjz.journals.ekb.eg/article_160272_8b4ee2ba58527af0be2446081b88235d.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
Virulence -Determinants and Antibiotic Resistance Pattern of Salmonella Species Isolated from Fancy Pigeons in Port-Said Governorate, Egypt
42
55
EN
ibrahim
El gresly
Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Suez Canal Univerisity, Ismailia, Egypt
ig_vet@yahoo.com
wael
Elfeil
Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Suez Canal Univerisity, Ismailia, Egypt
elfeil@vet.suez.edu.eg
reham
mokhtar
eltarabili
0000-0001-8273-2747
bacteriology,immunoloy and mycology department, faculty of veterinary medicine , Suez Canal University, Ismailia, Egypt
rehameltrabely@gmail.com
Hanan
Abdein
Department of Avian and Rabbit Medicine, Faculty of Veterinary Medicine, Suez Canal Univerisity, Ismailia, Egypt
hanan_24395@yahoo.com
10.21608/zvjz.2021.51547.1125
This study was carried out to investigate the prevalence of salmonellosis among fancy pigeons in Port- Said Governorate, Egypt. Two hundred (150 pet stores and 50 lofts) samples were collected from pigeons suffered from general signs of illness, joint lesions and diarrhea. Bacteriological and serological analysis revealed 12 (6%) isolate of <em>Salmonella</em> species distributed among eight serotypes, in which <em>S</em>. Virchow was more frequently isolated (25%), followed by <em>S</em>. Typhimurium and <em>S</em>. Paratyphi (16.6% each). Meanwhile, <em>S</em>. Akay, <em>S</em>. Salamae, <em>S</em>. Anderlecht, <em>S</em>. Magherafelt and <em>S</em>. Montevideo were 8.3%, each. All <em>Salmonella</em> isolates showed 100% sensitivity towards norfloxacin followed by ciprofloxacin (83.3%). On the other hand, ten Salmonella serotypes showed high resistance to erythromycin and rifampicin by 91.7 %. However, 42.1% of the recovered isolates exhibited Multi drug resistant (MDR) and 16.6% exhibited Extensive drug resistant (XDR) to different antibiotics. Molecular detection of 5 virulence genes (<em>inv</em>A<em>, stn, sop < /em>E1<em>, pef</em>Aand <em>fim</em>H) among four chosen Salmonella serotypes (<em>S</em>. Paratyphi, <em>S</em>. Typhimurium, <em>S</em>. Virchow, <em>S</em>. Montevideo) using conventional PCR revealed the presence of <em>inv</em>A, <em>stn</em> and f<em>im</em>H genes in all examined <em>Salmonella</em> serotypes. Meanwhile, <em>sop < /em>E1 and <em>pef</em>A genes were detected only between <em>S</em>. Virchow and <em>S</em>. Typhimurium, respectively.</em></em>
Pigeons,Salmonella,Serotypes,Virulence genes,MAR index
https://zvjz.journals.ekb.eg/article_160274.html
https://zvjz.journals.ekb.eg/article_160274_7729e911600dce74592f616ce6d1730c.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
The Influence of Intermittent Fasting Regimens on the Regulatory Mechanisms of Metabolic Health
56
66
EN
Khalifa
Ahmed
Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Sharkia 44511, Egypt
khalifaadawy@yahoo.co
Ahmed Hamed
Arisha
Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Sharkia 44511, Egypt
vetahmedhamed@yahoo.com.trackapp.io
Samar
Sharsher
Zagazig University Students Hospital, Zagazig University, Egypt.
ibrahimsemsem@gmail.com
10.21608/zvjz.2021.27440.1112
Intermittent fasting (IF) describes a variety of eating patterns during which no or few calories are consumed for certain time, which can range from twelve hours to some days, on a frequent basis. In recent years, IF became popular as a possible new paradigm for weight loss and inflammation reduction, as well as numerous health benefits. In this review, we incorporated various aspects of fasting, especially the effects of intermittent fasting diet (IFD) on lipid profile and inflammation as well as its effect on the body mass index and the glucose metabolism in non-diabetic people. Liver, cardiovascular and central nervous systems physiological responses are illustrated as well. An IFD may provide a huge metabolic benefit by improving glycemic control, insulin resistance, and adipokine concentration with a discount of body mass index in adults. Also, IF protocol helps improving several physiological functions thus inducing longevity and minimizing illness. Moreover, alternate day fasting (ADF) is considered as good protocol of food intake therapy for persons with non -alcoholic fatty liver disease (NAFLD), which can help in loss of weight and treatment of dyslipidemia within a relatively short period of time (a month to three months), and reduce cardiovascular risk factors. In conclusion, IF is suggested during the fight against many diseases as cancer, diabetes and central nervous system (CNS) disorders.
Keywords: : non -alcoholic fatty liver disease,Intermittent fasting,alternate day,calorie restriction,Lipid profile
https://zvjz.journals.ekb.eg/article_160276.html
https://zvjz.journals.ekb.eg/article_160276_1fe01b0f47deaf98911faa190e4451cb.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
Prevalence of Staphyloсoссus aureus and Streptococcus agalaсtiae isolated from Raw Milk in Dakahlia Governorate, Egypt
67
77
EN
Aya
Emam
Animal Health Research Institute ( Mansoura provincial lab)
aya_m_89@yahoo.com
Mohamed
El-Diasty
Mansoura provincial lab, Animal Health Research Institute
dr_mesbah_m@yahoo.com
Adel
Abdelkhalek
Department of Food hygiene and Control, Faculty of Veterinary medicine, Badr University, Egypt
adel.abdelkhalek@buc.edu.eg
10.21608/zvjz.2021.64186.1131
This study was carried out on 200 random milk samples сolleсted from different areas at Dakahlia Governorate for detection of prevalence and antimicrobial resistance of some zoonotic bacteria in milk as <em>Staphylococcus aureus</em> and Streptococci by using biochemical tests, antibiotic sensitivity test, PCR for confirmation and detection of some resistance and virulence genes. <em>Staphyloсoссus aureus </em>(<em>S. aureus</em>) was detected in 63%, 76%, and 42%, while <em>Streptococcus agalaсtiae </em>(<em>St. agalaсtiae) </em>was found in 8%, 10% and 4% of examined individual milk samples, retail milk samples, and milk of Bulk tank, respectively. <em>S. aureus </em>isolates revealed high levels of resistance to ampicillin (100%), nalidxiс acid (90%), oxaсillin (85%), peniсillin (85%), cefoxitin (75%), rifampin (25%), tetraсyсline (20%) and erythromyсin and sulphamethoxazole/ trimethoprim (10%). Whereas, <em>St. agalaсtiae</em> show high resistance to tetracycline (90%), ampiсillin (80%), rifampin (60%), sulphamethoxazole/ trimethoprim (50%), gentamyсin (45%), erythromyсin and nalidxiс aсid (40%)<strong>, </strong>cholorampheniсol (30%), and streptomyсin (25%). PСR results revealed that 4 out of 5 (80%) methicillin-resistant (MRSA) isolates had <em>meсA</em>and 2 (40%) had <em>meсС,</em>while 1 (20%) had <em>Sea</em>enterotoxin. Three isolates (100%) of <em>St. agalaсtiae</em> had <em>sul</em>1 gene and one out of three (33.3%) had <em>tetK</em> genes, while <em>dfrA</em> could not be detected. The main outcome of the current work is that milk can cause severe public health hazards to people because it had a variety of microorganisms. It is important to ensure using good hygienic practices in farms and prevent the haphazard abuse of antibiotics.
Raw milk samples,S. aureus,Strept. Agalaсtiae,antibiotic resistant,Resistant genes
https://zvjz.journals.ekb.eg/article_160279.html
https://zvjz.journals.ekb.eg/article_160279_cd0fdaf4797d5ec35c99d209dc8567c2.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
Resistin; a physiological overview
78
91
EN
mona
bakry
0000-0003-2406-1388
Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Egypt
mo.didamony@gmail.com
Noura
E. Abd El-Hameed
Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Egypt
snoura77@yahoo.com
Reda M.
Abd El-Aziz
Physiology Department, Faculty of Veterinary Medicine, Zagazig University,
44511, Egypt
redaabdelazziz81@yahoo.com
Mohamed
M. Z. Hamada
Department of Physiology, Faculty of Veterinary Medicine, Zagazig University
mo.didamony@yahoo.com
10.21608/zvjz.2021.62555.1130
Resistin is a novel peptide which is known to be an adipocyte-derived cytokine. It belongs to resistin like molecule family. It was revealed that resistin is an important link between obesity, insulin resistance and type 2 Diabetes Mellitus. After that, several investigations showed the important physiological activities of resistin apart from its role in insulin resistance and diabetes in many pathological conditions as cardiovascular diseases (as coronary thrombosis), malignancy, endothelial dysfunction, hypertension, thrombosis, angiogenesis, inflammation, asthma, autoimmune disease, atherosclerosis and chronic kidney disease. Moreover, several studies have underlined it’s participation in reproductive functions. It is well known that resistin expression is recorded in murine white adipose tissue but in human its expression is noticed in monocytes and macrophages. The mechanism of action, receptors and signaling pathways are beginning to be distinguished. In the present review, the present data concerning the discovery, structure, tissue distribution and functional role of resistin is summarized.
Resistin,Resistin like molecules family,inflammatory zone3,Adipokines
https://zvjz.journals.ekb.eg/article_160283.html
https://zvjz.journals.ekb.eg/article_160283_5fdcf257e1ef8d7e6dd901107a09d19b.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
"Troponin in Severe Pulmonary Stenosis, is it Important to Measure?"
92
101
EN
Mohammed
Eltahlawi
Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.
tahlawi_basha@yahoo.com
Mohammed
Morsy
Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.
mmorsyali@gmail.com
Mohammed
Elawady
Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.
mad59_3@gmail.com
Ahmed
Eldamanhory
Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.
damanhory.cardiology@yahoo.com
10.21608/zvjz.2021.51341.1124
Osteoarthritis (OA) is considered the prevalent arthritis in human and some animals, causing Pulmonary valve stenosis is a congenital disease in most of cases. The treatment of choice is balloon valvuloplasty (BPV) in human. Information is needed regarding analytical characteristics of cardiac troponin assays used in preclinical studies which usally are applied on animal models based on cummualtive knowledge of several studies in the last two deades we aim to assess the relationship between troponin biomarker and the severity of pulmonary valve stenosis. Thirty-sex patients with severe valvular pulmonary stenosis(PS) were recruited. Comparable control healthy group were involved. Serum troponin I was measured for all the sample populations. Echocardiographic evaluation of pulmonary valveand right ventricular (RV)function were done.Results:The estimated level of cardiac troponin thirty-sex patients with severe valvular PS was recruited, there was significant correlation between peak Systolic pressure gradient (SPG) and troponin in PS ( r = 0.768). There was a significant correlation between troponin level and the parameters of RV diastolicdysfunction (p < 0.001) (r=0.81).Troponin was significantly decreased 2 weeks after BPV (p < 0.01). Conclusion: seum cardiactroponin is elevated in valvular PS and correlates with its severity and associates with RV dysfunction. RV function improved after BPV associated with decrease in the troponin level in human. Troponin could be used as a biomarker for PS severity and the associated RV diastolic dysfunction in human. The human will benefit from relief of pulmonary stenosis by balloon valvoplasty as in our study and other studies which made on animals with pulmonarystenosis
Pulmonary stenosis,troponin,Tissue Doppler,Baloon valvuloplasty,Re-stenosis
https://zvjz.journals.ekb.eg/article_160286.html
https://zvjz.journals.ekb.eg/article_160286_b633567fe272a87226087b8bef55ec5b.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
The Ameliorative Role of Cranberry Extract Use on Hematological Changes Induced by Lead acetate in Rats
102
113
EN
Hussein
El-Belbasy
Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University - 44511, Zagazig, Egypt.
h.elbelbasi2017@gmail.com
Mohammed
Hussein
0000-0002-1811-2794
Department of Biochemistry, Faculty of Applied Medical Sciences, October 6 University - 12585, Giza, Egypt
prof.husseinma@o6u.edu.eg
Mohamed
El-Ghitany
0000-0003-3412-3239
Department of Biochemistry, Faculty of Applied Medical Sciences, October 6 University - 12585, Giza, Egypt
m.alghitany90@gmail.com
10.21608/zvjz.2021.55792.1132
Lead poisonousness is a widely recognized type of heavy metal poisoning in humans and animals. So, this study aimed to assess the ameliorative role of cranberry extract use on hematological changes induced by lead acetate in rats. A total number of 40 adult male albino rats weighing approximately 200 ± 20 g were randomly assigned into four groups; Normal control group, group 2; Positive control, lead acetate at a dose of (50 PPM) for 45 days, group 3; Lead acetate at a dose of (50 PPM) then Cranberry extract (75 mg/kg) for 45 days also group 4; Lead acetate (50 PPM) then Cranberry extract (150 mg/kg) for 45 days. Blood samples were collected in EDTA tubes for hematological examinations. Oral administration of lead acetate (50 PPM) significantly decreased total erythrocyte count, hemoglobin, packed cell volume and mean cell volume levels in comparison with the normal control group <em>(P< 0.0001)</em>. Addition of cranberry extract at a dose of 75 and 150 mg/kg significantly increased the total erythrocyte count, hemoglobin, packed cell volume and mean cell volume levels in comparison with the positive control group <em>(P< 0.0001)</em>. Oral administration of lead acetate (50 PPM) significantly increased total leukocytes count, lymphocyte, neutrophils, eosinophil and monocytes count in comparison with the normal control group <em>(P< 0.0001)</em>. Addition of cranberry extract at a dose of 75 and 150 mg/kg significantly decreased the total leukocytes count, lymphocyte, neutrophils, eosinophil and monocytes count in comparison with the positive control group <em>(P< 0.0001)</em>. Our results clearly indicate that cranberry extract ameliorates hematological changes in lead acetate-treated rats.
Lead-induced toxicity,Oxidative Stress,Cranberry extract,Hematological investigations
https://zvjz.journals.ekb.eg/article_160292.html
https://zvjz.journals.ekb.eg/article_160292_6dbb4358e707138bd312ea988efd1165.pdf
Zagazig University, Faculty of Veterinary Medicine
Zagazig Veterinary Journal
1110-1458
2357-075X
49
1
2021
03
01
Glutathione Metabolism in Rat Tissue
114
123
EN
Medhat
Fawzy
Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Egypt
drmedhatfawzy49@yahoo.com
Doaa
Abdel-Fattah
Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, 44511 Zagazig, Egypt
drdoaa30@gmail.com
Reham
Ibrahim
Environmental Affairs Agency, Ministry of Environment, Zagazig
rehamalwakeel22@gmail.com
10.21608/zvjz.2021.50988.1129
The present research was designed to study the positive effect of curcumin and the bad effects of dietary high fat diet (beef tallow) which causes nonalcoholic fatty liver disease, very harmful affecting health, also our study was designed to study the important role of curcumin, against (HFD-induced obesity). Sixty male albino rats weighing( 165-170gm), were be obtained from animal house at the Faculty of Veterinary Medicine ,Zagazig University .After acclimatization at 23-25 <sup>0</sup>Cand and free availability of water and diet rats were divided into four main groups, each contains 15 rats for 12 weeks.G1(Control),G2(Curcumin),G3(HFD),G4(HFD+cur) .At the end of the experiment, all rats were euthansized and blood collected weekly to biochemical examination during 12 weeks. Our results after statistical analysis revealed that showed that rats Fed on curcumin (3% w/w), had a significant increase in (total glutathione ,GSH, glutathione quotient) and a significant decrease in oxidized glutathione level in hepatic tissue ,a significant increase in the activity of liver glutathione peroxidase and reductase but a significant decrease in the glutathione state in rats fed on beef tallow on G3 (HFD) when compared to the control group .a significant increase in glutathione state in G4(HFD+CUR) when compared to G3(HFD). our results revealed a significant increase in insulin level ,HDL ,and a significant decrease in blood glucose, TAG, total cholesterol ,MDA ,LDL in G2(Curcumin) and (HFD+CUR) but a small significant decrease in total bilirubin in only (HFD+CUR) group when compared to group 3(HFD). A significant decrease in insulin level, HDL-c in G3(HFD)when compared to curcumin group a significant increase in blood glucose, TAG , TC ,LDL-c ,VLDL, MDA, bilirubin in high fat diet .Rats fed on curcumin 3% showed a significant decrease in body weight gain but rats fed on beef tallow revealed a significant increase in body weight.
Non alcoholic fatty liver disease,glutathione peroxidase(GPX),Glutathione reductase (GR),Curcumin,HFD
https://zvjz.journals.ekb.eg/article_160293.html
https://zvjz.journals.ekb.eg/article_160293_5267e306a2e21dcab1a2a3a133abfb3c.pdf