Effect of Some Antioxidants on Some Liver Growth Factors

According to most researchers all types of liver affections are associated with oxidative brunt that affects proteins, nucleic acids, and lipid bi-layer plasma membranes. In this work experimental animals (male albino rats) were fed thermally treated oil and ethanol alcohol as inducers of liver affections. Vitamin E and Curcumin were administered to those animals in a trial to investigate their ability to combat with this oxidative attack .Malondialdyhyde(MDA) was assayed as a measure of the oxidative affections. Since liver regeneration needs the participation and cooperation of other factors, growth factors (HGF, TGFα and TGFβ were assayed in liver homogenates of the sacrificed rats. Results showed that. Antioxidant enzymes levels   were significantly low in animals treated with oil or ethanol as compared to control .These levels were improved on giving either vitamin E or Curcumin as exogenous antioxidants
Cucuminn was more powerful than vitamin E in this respect
The elevated growth factors in animals with oxidative attack were declined on administration of curcumin or vitamin E
 The liver functions measured were just a mirror or reflection of liver pathology induced by oxidant agents
 More work is needed to add other natural antioxidants, investigate their mechanism of action and to ascertain the optimum period of their use, and mode of supplementing them