Pharmacological Studies on Bleomycin as Cancer Therapy and Protective Effect of Aged Garlic

Document Type : Original Article

Authors

1 Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt

2 Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt

Abstract

The pharmacological impacts of bleomycin as anticarcinogenic agents and the protective effect of aged garlic were done in current study. Eighty mature male albino mice were divided into 8 groups (each ten mice), group one was kept as a negative control, group two which was injected intraperoteneally with bleomycin. Group 3,  which was given orally aged garlic, group 4 was inoculated with Ehrlich Ascites Carcinoma cells (EAC) , animals of group 5were administrated aged garlic and injected  with EAC cells while group 6 was given simultaneously  EAC cells and bleomycin I/P  ,  group 7 was  injected bleomycin I/P and administrated  garlic 8 days  later and group 8 took  both bleomycin and garlic before inoculation of EAC cells by 8 days. Our results revealed that there were side effects of bleomycin   on GSH, ROS, CAT, GPX and GR in the inoculated groups with EAC cells and confirmed by biochemical analysis. Aged garlic suppresses the progression of EAC cells and prevents their developmental effects

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