Residues of Ciprofloxacin in Rabbit Tissues by HPLC

Document Type : Original Article

Authors

1 Chemistry Department, Animal Health Research Institute, Dokki, Giza, Egypt

2 Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, 44511, Egypt

Abstract

The current study aimed to determine residues of ciprofloxacin in different rabbit tissues (liver, muscles, kidneys, spleen, heart and lungs) and sera following administration of multiple oral doses. Twenty five rabbits were given the drug at a dose of 5 mg/kg BW for five successive days and then samples were collected at 1st, 3rd, 5th, 7th, 9th, 15th and 21st day after last oral dose. The results indicated a widespread distribution of ciprofloxacin in the tested tissues except in the heart. The drug remained within the detectable limit till the 3rd day in most tested tissues, while in kidneys it remained till the 5th day following the last oral administration of the drug. Therefore, muscles of rabbits could be eaten safely in the 3rd day post treatment, while liver and kidneys could be eaten safely in the 5th day after treatment without any hazards on consumers.

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Zagazig Veterinary Journal
Volume 43, Issue 3
December 2015
Pages 28-36

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